I had a great meeting today with Catherine in the Developer Evangelism team. She turned me on to a webpage I missed at PDC which articulates how to archictect applications for Windows Vista.  There's a lot of good detail here- beyond the traditional marketing fluff.

http://msdn.microsoft.com/windowsvista/top10/

But what do you think?  What would you like to see covered/detailed further? I'll pass the team your feedback.